Endocrine Abstracts

Aims and Methods:Obesity treatment is often unsuccessful despite the efforts of seemingly motivated patients. Awareness among the obese, regarding obesity, is important to facilitate weight loss and to prevent weight gain. We assessed the awareness of obese patients with regard to obesity, its complications and treatment options. Consecutive subjects attending outpatient clinics with BMI>/=30and <70years of age were interviewed.<p class="abstex...

Various criteria have been proposed to diagnose and treat gestational diabetes due to uncertainties about the influence of mild degrees of maternal glucose intolerance on pregnancy outcomes. We used receiver operating characteristics (ROC) curve analysis to correlate macrosomia (more than or equal to 4000g) with varying thresholds for the 2 hour 75 gm oral glucose tolerance test (OGTT) results in pregnant women screened at our hospital from 1998-2001.Wom...

Management of Thyrotoxicosis in a Non-compliant Pregnant WomanA 23-year-old woman with Grave's disease presented to thyroid clinic 29 weeks into her first pregnancy having recently moved into the area. She had failed to attend hospital thyroid clinics elsewhere and frequently changed her address.Despite propylthiouracil 300 mg daily she had marked tremor, tachycardia 100 bpm, ophthalmopathy, and a large smooth goitre. TSH <0.0...

The presence of thyroid peroxidase antibodies (TPOAb) is a marker of autoimmune thyroid disease and, when present in early pregnancy, is predictive of postpartum thyroiditis. In the course of undertaking the Controlled Antenatal Thyroid Screening Study we have taken the opportunity to measure TPOAb in a large number of samples from 11–16 weeks gestation by 3 different assays.The assays were (1) an in-house ELISA; (2) Bayer ADVIA Centaur anti-TPO ass...

Aims and MethodsBone density (BMD) measurement is essential to assess the skeletal impact of primary hyperparathyroidism (PHPT). Coexistent osteoporosis is one of the criteria to consider parathyroidectomy in PHPT. PHPT is associated with predominant bone loss at the wrist. Assessment of BMD at this site is important to identify all patients with osteoporosis. Repeat BMDmeasurements are imperative to assess progression of disease, response to treatment a...

Rationale and aim: The incidence of intracranial aneurysms (IA) appears increased in patients with PAs/PitNETs. Changes in hemodynamics and vascular structure secondary to mass effect, inflammation, and hormonal changes (primarily, GH hypersecretion) have been suggested as risk factors. Study aim was to define typical features, timing of occurrence and treatment, and identify risk factors in patients with PA/PitNET and IA.Patients and methods: Data of 57...